8BJU
HUMAN WEE1 KINASE IN COMPLEX WITH INHIBITOR 1-[6-(1-Hydroxy-1-methyl-ethyl)-pyridin-2-yl]-2-(2-methoxy-phenyl)-6-[4-(4-methyl-piperazin-1-yl)-phenylamino]-1,2-dihydro-pyrazolo[3,4-d]pyrimidin-3-one
Summary for 8BJU
Entry DOI | 10.2210/pdb8bju/pdb |
Descriptor | Wee1-like protein kinase, 2-(2-methoxyphenyl)-6-[[4-(4-methylpiperazin-1-yl)phenyl]amino]-1-[6-(2-oxidanylpropan-2-yl)pyridin-2-yl]pyrazolo[3,4-d]pyrimidin-3-one (3 entities in total) |
Functional Keywords | wee1, kinase, protein-inhibitor complex, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 32735.29 |
Authors | |
Primary citation | Guler, S.,DiPoto, M.C.,Crespo, A.,Caldwell, R.,Doerfel, B.,Grossmann, N.,Ho, K.,Huck, B.,Jones, C.C.,Lan, R.,Musil, D.,Potnick, J.,Schilke, H.,Sherer, B.,Simon, S.,Sirrenberg, C.,Zhang, Z.,Liu-Bujalski, L. Selective Wee1 Inhibitors Led to Antitumor Activity In Vitro and Correlated with Myelosuppression. Acs Med.Chem.Lett., 14:566-576, 2023 Cited by PubMed: 37197456DOI: 10.1021/acsmedchemlett.2c00481 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.53 Å) |
Structure validation
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