8BJH

chimera of the inactive ExoY Nucleotidyl Cyclase domain from Vibrio nigripulchritudo MARTX toxin, with the double mutation K3528M and K3535I, fused to a proline-Rich-Domain (PRD) and profilin, bound to Latrunculin B-ADP-Mg-actin

8BJH の概要

• エントリーDOI: 10.2210/pdb8bjh/pdb
• 関連するPDBエントリー: 7PJ0 7PQJ 7PSB
• 分子名称: Actin, alpha skeletal muscle, intermediate form, DI(HYDROXYETHYL)ETHER, Putative Adenylate cyclase,Profilin-1, ... (11 entities in total)
• 機能のキーワード: bacterial nucleotidyl cyclase toxin, activated complex, toxin
• 由来する生物種: Vibrio nigripulchritudo; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 109019.43

構造登録者

Teixeira-Nunes, M.,Renault, L.,Retailleau, P. (登録日: 2022-11-04, 公開日: 2023-09-20, 最終更新日: 2023-10-04)

• 主引用文献: Teixeira-Nunes, M.,Retailleau, P.,Raoux-Barbot, D.,Comisso, M.,Missinou, A.A.,Velours, C.,Plancqueel, S.,Ladant, D.,Mechold, U.,Renault, L.; Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin.; Plos Pathog., 19:e1011654-e1011654, 2023; PubMed: 37747912; DOI: 10.1371/journal.ppat.1011654

実験手法

X-RAY DIFFRACTION (1.69 Å)