8BJ5
Imine Reductase IR007 from Amycolatopsis azurea
Summary for 8BJ5
| Entry DOI | 10.2210/pdb8bj5/pdb |
| Descriptor | Imine Reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (3 entities in total) |
| Functional Keywords | amine, imine nadph, biocatalyst, oxidoreductase |
| Biological source | Amycolatopsis azurea |
| Total number of polymer chains | 4 |
| Total formula weight | 126942.52 |
| Authors | Gilio, A.K.,Steflik, J.,Grogan, G. (deposition date: 2022-11-03, release date: 2023-09-20, Last modification date: 2026-03-04) |
| Primary citation | Steflik, J.,Gilio, A.,Burns, M.,Grogan, G.,Kumar, R.,Lewis, R.,Martinez, C. Engineering of a Reductive Aminase to Enable the Synthesis of a Key Intermediate to a CDK 2/4/6 Inhibitor Acs Catalysis, 13:10065-10075, 2023 Cited by DOI: 10.1021/acscatal.3c01534PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.72 Å) |
Structure validation
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