8BIW

Cystathionine gamma-lyase N360S mutant in complex with DL-propargylglycine

Summary for 8BIW

• Entry DOI: 10.2210/pdb8biw/pdb
• Descriptor: Cystathionine beta-lyase, putative, (2S)-2-aminopent-4-enoic acid, PYRIDOXAL-5'-PHOSPHATE, ... (4 entities in total)
• Functional Keywords: transsulfuration pathway, hydrogen sulfide, propargylglycine, toxoplasma, cytosolic protein
• Biological source: Toxoplasma gondii
• Total number of polymer chains: 2
• Total formula weight: 92633.54

Authors

Fernandez-Rodriguez, C.,Conter, C.,Oyenarte, I.,Favretto, F.,Quintana, I.,Martinez-Chantar, M.L.,Astegno, A.,Martinez-Cruz, L.A. (deposition date: 2022-11-02, release date: 2023-04-12, Last modification date: 2024-02-07)

• Primary citation: Fernandez-Rodriguez, C.,Conter, C.,Oyenarte, I.,Favretto, F.,Quintana, I.,Martinez-Chantar, M.L.,Astegno, A.,Martinez-Cruz, L.A.; Structural basis of the inhibition of cystathionine gamma-lyase from Toxoplasma gondii by propargylglycine and cysteine.; Protein Sci., 32:e4619-e4619, 2023; PubMed: 36883335; DOI: 10.1002/pro.4619

Experimental method

X-RAY DIFFRACTION (1.981 Å)