8B54

CDK2/cyclin A2 in complex with pyrazolo[4,3-d]pyrimidine inhibitor LGR6768

Summary for 8B54

Entry DOI	10.2210/pdb8b54/pdb
Descriptor	Cyclin-dependent kinase 2, Cyclin-A2, ~{N}-[(2-phenylphenyl)methyl]-5-piperidin-4-ylsulfanyl-3-propan-2-yl-2~{H}-pyrazolo[4,3-d]pyrimidin-7-amine, ... (6 entities in total)
Functional Keywords	cyclin-dependent kinase 2, cyclin a2, cancer, cell cycle
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	128945.44
Authors	Djukic, S.,Skerlova, J.,Rezacova, P. (deposition date: 2022-09-21, release date: 2023-03-29, Last modification date: 2024-02-07)
Primary citation	Kovalova, M.,Havlicek, L.,Djukic, S.,Skerlova, J.,Perina, M.,Pospisil, T.,Reznickova, E.,Rezacova, P.,Jorda, R.,Krystof, V. Characterization of new highly selective pyrazolo[4,3-d]pyrimidine inhibitor of CDK7. Biomed Pharmacother, 161:114492-114492, 2023 Cited by PubMed: 36931035 DOI: 10.1016/j.biopha.2023.114492 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation