8B47
Crystal structure of NAD kinase 1 from Listeria monocytogenes in complex with a cyclic di-adenosine derivative
Summary for 8B47
Entry DOI | 10.2210/pdb8b47/pdb |
Related | 7ZZ7 |
Descriptor | NAD kinase 1, (1~{R},23~{R},24~{S},25~{R})-14-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl]-7-azanyl-24,25-bis(oxidanyl)-20,20-bis(oxidanylidene)-26-oxa-20$l^{6}-thia-2,4,6,9,14,17,21-heptazatetracyclo[21.2.1.0^{2,10}.0^{3,8}]hexacosa-3,5,7,9-tetraen-11-yn-16-one, PENTAETHYLENE GLYCOL, ... (5 entities in total) |
Functional Keywords | tetrameric nad-kinase, transferase |
Biological source | Listeria monocytogenes EGD-e |
Total number of polymer chains | 2 |
Total formula weight | 63950.17 |
Authors | Gelin, M.,Labesse, G. (deposition date: 2022-09-20, release date: 2023-01-11, Last modification date: 2024-01-31) |
Primary citation | Clement, D.A.,Gelin, M.,Leseigneur, C.,Huteau, V.,Mondange, L.,Pons, J.L.,Dussurget, O.,Lionne, C.,Labesse, G.,Pochet, S. Synthesis and structure-activity relationship studies of original cyclic diadenosine derivatives as nanomolar inhibitors of NAD kinase from pathogenic bacteria. Eur.J.Med.Chem., 246:114941-114941, 2023 Cited by PubMed: 36455355DOI: 10.1016/j.ejmech.2022.114941 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.53 Å) |
Structure validation
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