8B10
Crystal Structure of Shank2-SAM mutant domain - L1800W
Summary for 8B10
Entry DOI | 10.2210/pdb8b10/pdb |
Descriptor | SH3 and multiple ankyrin repeat domains protein 2, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, ... (5 entities in total) |
Functional Keywords | synaptic scaffold protein; zn2+ binding; zn-dependent polymerization;, metal binding protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 6 |
Total formula weight | 49491.84 |
Authors | Bento, I.,Gracia Alai, M.,Kreienkamp, J.-H. (deposition date: 2022-09-08, release date: 2022-11-30, Last modification date: 2024-09-11) |
Primary citation | Hassani Nia, F.,Woike, D.,Bento, I.,Niebling, S.,Tibbe, D.,Schulz, K.,Hirnet, D.,Skiba, M.,Honck, H.H.,Veith, K.,Gunther, C.,Scholz, T.,Bierhals, T.,Driemeyer, J.,Bend, R.,Failla, A.V.,Lohr, C.,Alai, M.G.,Kreienkamp, H.J. Structural deficits in key domains of Shank2 lead to alterations in postsynaptic nanoclusters and to a neurodevelopmental disorder in humans. Mol Psychiatry, 29:1683-1697, 2024 Cited by PubMed: 36450866DOI: 10.1038/s41380-022-01882-3 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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