8CRK
Crystal structure of N-terminal SARS-CoV-2 nsp1 in complex with fragment hit 7H2 refined against anomalous diffraction data
Replaces: 8AYWSummary for 8CRK
Entry DOI | 10.2210/pdb8crk/pdb |
Descriptor | Host translation inhibitor nsp1, (1~{R})-1-(4-chlorophenyl)ethanamine (3 entities in total) |
Functional Keywords | sars-cov-2, non-structural protein 1, fragment hit, anomalous diffraction, viral protein |
Biological source | Severe acute respiratory syndrome coronavirus 2 |
Total number of polymer chains | 1 |
Total formula weight | 13264.78 |
Authors | Ma, S.,Mikhailik, V.,Pinotsis, N.,Bowler, M.W.,Kozielski, F. (deposition date: 2023-03-08, release date: 2023-10-04) |
Primary citation | Ma, S.,Mykhaylyk, V.,Bowler, M.W.,Pinotsis, N.,Kozielski, F. High-Confidence Placement of Fragments into Electron Density Using Anomalous Diffraction-A Case Study Using Hits Targeting SARS-CoV-2 Non-Structural Protein 1. Int J Mol Sci, 24:-, 2023 Cited by PubMed: 37446375DOI: 10.3390/ijms241311197 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.1 Å) |
Structure validation
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