8AYF

Crystal structure of human Sphingosine-1-phosphate lyase 1

8AYF の概要

• エントリーDOI: 10.2210/pdb8ayf/pdb
• 分子名称: Sphingosine-1-phosphate lyase 1, ACETATE ION, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: s1p, lipid, lyase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 110298.79

構造登録者

Giardina, G.,Catalano, F.,Pampalone, G.,Cellini, B. (登録日: 2022-09-02, 公開日: 2023-09-13, 最終更新日: 2024-01-03)

• 主引用文献: Cellini, B.,Pampalone, G.,Camaioni, E.,Pariano, M.,Catalano, F.,Zelante, T.,Dindo, M.,Macchioni, L.,Di Veroli, A.,Galarini, R.,Paoletti, F.,Davidescu, M.,Stincardini, C.,Vascelli, G.,Bellet, M.M.,Saba, J.,Giovagnoli, S.,Giardina, G.,Romani, L.,Costantini, C.; Dual species sphingosine-1-phosphate lyase inhibitors to combine antifungal and anti-inflammatory activities in cystic fibrosis: a feasibility study.; Sci Rep, 13:22692-22692, 2023; PubMed: 38123809; DOI: 10.1038/s41598-023-50121-4

実験手法

X-RAY DIFFRACTION (1.84 Å)