8AXD

Human serotonin 5-HT3A receptor (apo, resting conformation)

Summary for 8AXD

Entry DOI	10.2210/pdb8axd/pdb
EMDB information	15699
Descriptor	5-hydroxytryptamine receptor 3A, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
Functional Keywords	human pentameric ligand-gated ion channel, human serotonin receptor, membrane protein
Biological source	Homo sapiens (human)
Total number of polymer chains	5
Total formula weight	317337.14
Authors	Lopez-Sanchez, U.,Nury, H. (deposition date: 2022-08-31, release date: 2024-03-06, Last modification date: 2024-05-15)
Primary citation	Lopez-Sanchez, U.,Munro, L.J.,Ladefoged, L.K.,Pedersen, A.J.,Brun, C.C.,Lyngby, S.M.,Baud, D.,Juillan-Binard, C.,Pedersen, M.G.,Lummis, S.C.R.,Bang-Andersen, B.,Schiott, B.,Chipot, C.,Schoehn, G.,Neyton, J.,Dehez, F.,Nury, H.,Kristensen, A.S. Structural determinants for activity of the antidepressant vortioxetine at human and rodent 5-HT 3 receptors. Nat.Struct.Mol.Biol., 2024 Cited by PubMed: 38698207 DOI: 10.1038/s41594-024-01282-x PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.98 Å)

Structure validation