8AXD

Human serotonin 5-HT3A receptor (apo, resting conformation)

8AXD の概要

• エントリーDOI: 10.2210/pdb8axd/pdb
• EMDBエントリー: 15699
• 分子名称: 5-hydroxytryptamine receptor 3A, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• 機能のキーワード: human pentameric ligand-gated ion channel, human serotonin receptor, membrane protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 317337.14

構造登録者

Lopez-Sanchez, U.,Nury, H. (登録日: 2022-08-31, 公開日: 2024-03-06, 最終更新日: 2024-05-15)

• 主引用文献: Lopez-Sanchez, U.,Munro, L.J.,Ladefoged, L.K.,Pedersen, A.J.,Brun, C.C.,Lyngby, S.M.,Baud, D.,Juillan-Binard, C.,Pedersen, M.G.,Lummis, S.C.R.,Bang-Andersen, B.,Schiott, B.,Chipot, C.,Schoehn, G.,Neyton, J.,Dehez, F.,Nury, H.,Kristensen, A.S.; Structural determinants for activity of the antidepressant vortioxetine at human and rodent 5-HT 3 receptors.; Nat.Struct.Mol.Biol., 2024; PubMed: 38698207; DOI: 10.1038/s41594-024-01282-x

実験手法

ELECTRON MICROSCOPY (2.98 Å)