8AWW

Transthyretin conjugated with a tafamidis derivative

Summary for 8AWW

• Entry DOI: 10.2210/pdb8aww/pdb
• Related: 3tct
• Descriptor: Transthyretin, ~{N}-(6-azanylhexyl)-2-[3,5-bis(chloranyl)phenyl]-1,3-benzoxazole-6-carboxamide (3 entities in total)
• Functional Keywords: ttr, tafamidis, protein-drug conjugates, drug design, cancer therapy., transport protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 26219.05

Authors

Cerofolini, L.,Vasa, K.,Bianconi, E.,Salobehaj, M.,Cappelli, G.,Licciardi, G.,Perez-Rafols, A.,Padilla Cortes, L.D.,Antonacci, S.,Rizzo, D.,Ravera, E.,Calderone, V.,Parigi, G.,Luchinat, C.,Macchiarulo, A.,Menichetti, S.,Fragai, M. (deposition date: 2022-08-30, release date: 2023-07-12, Last modification date: 2024-02-07)

• Primary citation: Cerofolini, L.,Vasa, K.,Bianconi, E.,Salobehaj, M.,Cappelli, G.,Bonciani, A.,Licciardi, G.,Perez-Rafols, A.,Padilla-Cortes, L.,Antonacci, S.,Rizzo, D.,Ravera, E.,Viglianisi, C.,Calderone, V.,Parigi, G.,Luchinat, C.,Macchiarulo, A.,Menichetti, S.,Fragai, M.; Combining Solid-State NMR with Structural and Biophysical Techniques to Design Challenging Protein-Drug Conjugates.; Angew.Chem.Int.Ed.Engl., 62:e202303202-e202303202, 2023; PubMed: 37276329; DOI: 10.1002/anie.202303202

Experimental method

X-RAY DIFFRACTION (1.6 Å)