8AWT

IAPP S20G lag-phase fibril polymorph 2PF-P

Summary for 8AWT

• Entry DOI: 10.2210/pdb8awt/pdb
• EMDB information: 15696
• Descriptor: Islet amyloid polypeptide (1 entity in total)
• Functional Keywords: amyloid, fibril, helical, cross-beta, amylin, polymorph, islet, protein fibril, diabetes
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 10
• Total formula weight: 38772.86

Authors

Wilkinson, M.,Xu, Y.,Gallardo, R.,Radford, S.E.,Ranson, N.A. (deposition date: 2022-08-30, release date: 2024-01-10)

• Primary citation: Wilkinson, M.,Xu, Y.,Thacker, D.,Taylor, A.I.P.,Fisher, D.G.,Gallardo, R.U.,Radford, S.E.,Ranson, N.A.; Structural evolution of fibril polymorphs during amyloid assembly.; Cell, 186:5798-5811.e26, 2023; PubMed: 38134875; DOI: 10.1016/j.cell.2023.11.025

Experimental method

ELECTRON MICROSCOPY (3 Å)