8ATY
Crystal structure of PPAR gamma (PPARG) in complex with JP85 (compound 1).
Summary for 8ATY
| Entry DOI | 10.2210/pdb8aty/pdb |
| Descriptor | Peroxisome proliferator-activated receptor gamma, 2-[4-chloranyl-6-(5,6,7,8-tetrahydronaphthalen-1-ylamino)pyrimidin-2-yl]sulfanylethanoic acid, GLYCEROL, ... (4 entities in total) |
| Functional Keywords | nuclear receptor, pparg, inhibitor, structural genomics, structural genomics consortium, sgc, nuclear protein |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 32827.93 |
| Authors | Chaikuad, A.,Pollinger, J.,Merk, D.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2022-08-24, release date: 2023-07-12, Last modification date: 2024-02-07) |
| Primary citation | Arifi, S.,Marschner, J.A.,Pollinger, J.,Isigkeit, L.,Heitel, P.,Kaiser, A.,Obeser, L.,Hofner, G.,Proschak, E.,Knapp, S.,Chaikuad, A.,Heering, J.,Merk, D. Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPAR gamma Modulation. J.Am.Chem.Soc., 145:14802-14810, 2023 Cited by PubMed: 37385602DOI: 10.1021/jacs.3c03417 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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