8AOP

Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with compound 14r

8AOP の概要

• エントリーDOI: 10.2210/pdb8aop/pdb
• 分子名称: Cereblon isoform 4, ZINC ION, (3S)-3-[(3-aminophenyl)sulfanylmethyl]piperidine-2,6-dione, ... (5 entities in total)
• 機能のキーワード: proteolysis targeting chimera, protac, protein degradation, signaling protein
• 由来する生物種: Magnetospirillum gryphiswaldense MSR-1
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 41784.30

構造登録者

Maiwald, S.,Heim, C.,Hartmann, M.D. (登録日: 2022-08-08, 公開日: 2023-01-11, 最終更新日: 2024-02-07)

• 主引用文献: Krasavin, M.,Adamchik, M.,Bubyrev, A.,Heim, C.,Maiwald, S.,Zhukovsky, D.,Zhmurov, P.,Bunev, A.,Hartmann, M.D.; Synthesis of novel glutarimide ligands for the E3 ligase substrate receptor Cereblon (CRBN): Investigation of their binding mode and antiproliferative effects against myeloma cell lines.; Eur.J.Med.Chem., 246:114990-114990, 2023; PubMed: 36476642; DOI: 10.1016/j.ejmech.2022.114990

実験手法

X-RAY DIFFRACTION (1.944 Å)