8ANS

Crystal structure of D1228V c-MET bound by compound 1.

Summary for 8ANS

Entry DOI	10.2210/pdb8ans/pdb
Descriptor	Hepatocyte growth factor receptor, GLYCEROL, 3-[bis(fluoranyl)methyl]-~{N}-methyl-~{N}-[(1~{R})-8-methyl-5-(3-methyl-1~{H}-indazol-6-yl)-1,2,3,4-tetrahydronaphthalen-1-yl]pyridine-2-carboxamide, ... (4 entities in total)
Functional Keywords	kinase, inhibitor, ac-helix, cancer, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	34008.52
Authors	Collie, G.W. (deposition date: 2022-08-05, release date: 2022-08-31, Last modification date: 2024-01-31)
Primary citation	Collie, G.W.,Barlind, L.,Bazzaz, S.,Borjesson, U.,Dale, I.L.,Disch, J.S.,Habeshian, S.,Jetson, R.,Khurana, P.,Madin, A.,Michaelides, I.N.,Peng, L.,Snijder, A.,Stubbs, C.J. Discovery of a selective c-MET inhibitor with a novel binding mode. Bioorg.Med.Chem.Lett., 75:128948-128948, 2022 Cited by PubMed: 35987508 DOI: 10.1016/j.bmcl.2022.128948 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.01 Å)

Structure validation