8AM6

Cyclohexanone dehydrogenase (CDH) from Alicycliphilus denitrificans K601 complexed with dehydrogenated substrate cyclohex-2-en-1-one - inactive mutant (Y195F)

This is a non-PDB format compatible entry.

Summary for 8AM6

• Entry DOI: 10.2210/pdb8am6/pdb
• Related: 8AM3
• Descriptor: Fumarate reductase/succinate dehydrogenase flavoprotein domain protein, FLAVIN-ADENINE DINUCLEOTIDE, cyclohex-2-en-1-one, ... (6 entities in total)
• Functional Keywords: fad, cyclic ketone, enzyme engineering, rational design, flavoprotein
• Biological source: Alicycliphilus denitrificans K601
• Total number of polymer chains: 2
• Total formula weight: 134798.40

Authors

Prior, S.H.,Taylor, E.J. (deposition date: 2022-08-02, release date: 2024-02-14, Last modification date: 2024-04-10)

• Primary citation: Singh, W.,Brown, N.L.,McCue, H.V.,Marriott, S.R.,Wilson, R.C.,Perry, J.,Turkenburg, J.P.,Dubey, K.D.,Prior, S.H.,Carnell, A.J.,Taylor, E.J.,Black, G.W.; Rational design of a cyclohexanone dehydrogenase for enhanced alpha , beta-desaturation and substrate specificity.; Chem Sci, 15:4969-4980, 2024; PubMed: 38550701; DOI: 10.1039/d3sc04009g

Experimental method

X-RAY DIFFRACTION (1.33 Å)