8AM2

Human butyrylcholinesterase in complex with 2,2'-(((1E,1'E)-(2-phenylpyrimidine-4,6-diyl)bis(methaneylylidene))bis(hydrazin-1-yl-2-ylidene))bis(N,N,N-trimethyl-2-oxoethan-1-aminium)

Summary for 8AM2

Entry DOI	10.2210/pdb8am2/pdb
Descriptor	Cholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ~{N}-[(~{E})-[2-phenyl-6-[[2-[2-(trimethyl-$l^{4}-azanyl)ethanoyl]hydrazinyl]methyl]pyrimidin-4-yl]methylideneamino]-2-(trimethyl-$l^{4}-azanyl)ethanamide, ... (8 entities in total)
Functional Keywords	inhibitor, complex, butyrylcholinesterase, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	62764.69
Authors	Nachon, F.,Brazzolotto, X.,Dias, J. (deposition date: 2022-08-02, release date: 2023-06-14, Last modification date: 2024-02-07)
Primary citation	Nachon, F.,Brazzolotto, X.,Dias, J.,Courageux, C.,Drozdz, W.,Cao, X.Y.,Stefankiewicz, A.R.,Lehn, J.M. Grid-Type Quaternary Metallosupramolecular Compounds Inhibit Human Cholinesterases through Dynamic Multivalent Interactions. Chembiochem, 23:e202200456-e202200456, 2022 Cited by PubMed: 36193860 DOI: 10.1002/cbic.202200456 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation