8ALX
Structure of human PD-L1 in complex with inhibitor
Summary for 8ALX
Entry DOI | 10.2210/pdb8alx/pdb |
Descriptor | Programmed cell death 1 ligand 1, 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE, AMINOMETHYLAMIDE, ACETATE ION, ... (5 entities in total) |
Functional Keywords | pd-l1, immunooncology, immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 16943.29 |
Authors | Rodriguez, I.,Grudnik, P.,Holak, T.,Magiera-Mularz, K. (deposition date: 2022-08-01, release date: 2023-08-16, Last modification date: 2023-09-20) |
Primary citation | Rodriguez, I.,Kocik-Krol, J.,Skalniak, L.,Musielak, B.,Wisniewska, A.,Ciesiolkiewicz, A.,Berlicki, L.,Plewka, J.,Grudnik, P.,Stec, M.,Siedlar, M.,Holak, T.A.,Magiera-Mularz, K. Structural and biological characterization of pAC65, a macrocyclic peptide that blocks PD-L1 with equivalent potency to the FDA-approved antibodies. Mol Cancer, 22:150-150, 2023 Cited by PubMed: 37679783DOI: 10.1186/s12943-023-01853-4 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.1 Å) |
Structure validation
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