8ALX

Structure of human PD-L1 in complex with inhibitor

8ALX の概要

• エントリーDOI: 10.2210/pdb8alx/pdb
• 分子名称: Programmed cell death 1 ligand 1, 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE, AMINOMETHYLAMIDE, ACETATE ION, ... (5 entities in total)
• 機能のキーワード: pd-l1, immunooncology, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 16943.29

構造登録者

Rodriguez, I.,Grudnik, P.,Holak, T.,Magiera-Mularz, K. (登録日: 2022-08-01, 公開日: 2023-08-16, 最終更新日: 2023-09-20)

• 主引用文献: Rodriguez, I.,Kocik-Krol, J.,Skalniak, L.,Musielak, B.,Wisniewska, A.,Ciesiolkiewicz, A.,Berlicki, L.,Plewka, J.,Grudnik, P.,Stec, M.,Siedlar, M.,Holak, T.A.,Magiera-Mularz, K.; Structural and biological characterization of pAC65, a macrocyclic peptide that blocks PD-L1 with equivalent potency to the FDA-approved antibodies.; Mol Cancer, 22:150-150, 2023; PubMed: 37679783; DOI: 10.1186/s12943-023-01853-4

実験手法

X-RAY DIFFRACTION (1.1 Å)