8AKG

Human Sirt6 in complex with ADP-ribose and fragment 4-amino-6-chlorobenzene-1,3-disulfonamide

Summary for 8AKG

• Entry DOI: 10.2210/pdb8akg/pdb
• Descriptor: NAD-dependent protein deacetylase sirtuin-6, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, ZINC ION, ... (10 entities in total)
• Functional Keywords: deacylase, fragment, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 70926.46

Authors

You, W.,Steegborn, C. (deposition date: 2022-07-29, release date: 2023-08-16)

• Primary citation: You, W.,Steegborn, C.; Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.82 Å)