8AKG

Human Sirt6 in complex with ADP-ribose and fragment 4-amino-6-chlorobenzene-1,3-disulfonamide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	NAD-dependent protein deacetylase sirtuin-6	polymer	302	33631.6	2	UniProt (Q8N6T7) Pfam (PF02146)	Homo sapiens (human)	Regulatory protein SIR2 homolog 6,SIR2-like protein 6
2	C, R (A, B)	[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE	non-polymer		559.3	2	Chemie (AR6)
3	D, S (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
4	E, T (A, B)	TETRAETHYLENE GLYCOL	non-polymer		194.2	2	Chemie (PG4)
5	F, Q (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
6	G (A)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	1	Chemie (PEG)
7	H, I, J, K, L... (A, B)	SULFATE ION	non-polymer		96.1	12	Chemie (SO4)
8	O, Z (A, B)	4-AMINO-6-CHLOROBENZENE-1,3-DISULFONAMIDE	non-polymer		285.7	2	Chemie (I7B)
9	AA, P (B, A)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
10	BA, CA (A, B)	water	water		18.0	181	Chemie (HOH)

Sequence modifications

A, B: 13 - 308 (UniProt: Q8N6T7)

PDB	External Database	Details
Gly 7	-	expression tag
Ile 8	-	expression tag
Asp 9	-	expression tag
Pro 10	-	expression tag
Phe 11	-	expression tag
Thr 12	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	67263.2
Non-Polymers*	Number of molecules	25
	Total formula weight	3663.3
All*	Total formula weight	70926.5

*Water molecules are not included.