8AH2

Crystal structure of human 14-3-3 zeta fused to the NPM1 peptide including phosphoserine-48

8AH2 の概要

• エントリーDOI: 10.2210/pdb8ah2/pdb
• 分子名称: 14-3-3 protein zeta/delta,Nucleophosmin (2 entities in total)
• 機能のキーワード: 14-3-3, nucleophosmin 1, npm1, b23, numatrin, ser48, phosphoserine binder, phosphothreonine binder, pentamer, phosphorylation, signaling protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 55274.11

構造登録者

Boyko, K.M.,Kapitonova, A.A.,Tugaeva, K.V.,Varfolomeeva, L.A.,Sluchanko, N.N. (登録日: 2022-07-20, 公開日: 2022-09-14, 最終更新日: 2024-01-31)

• 主引用文献: Kapitonova, A.A.,Tugaeva, K.V.,Varfolomeeva, L.A.,Boyko, K.M.,Cooley, R.B.,Sluchanko, N.N.; Structural basis for the recognition by 14-3-3 proteins of a conditional binding site within the oligomerization domain of human nucleophosmin.; Biochem.Biophys.Res.Commun., 627:176-183, 2022; PubMed: 36041327; DOI: 10.1016/j.bbrc.2022.08.047

実験手法

X-RAY DIFFRACTION (2.9 Å)