8AGK

Botulinum neurotoxin subtype A6 cell binding domain in complex with GD1a ganglioside

This is a non-PDB format compatible entry.

Summary for 8AGK

• Entry DOI: 10.2210/pdb8agk/pdb
• Descriptor: Bont/A1, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-alpha-D-galactopyranose-(1-4)-alpha-D-glucopyranose, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: botulism, ganglioside, botulinum neurotoxin, cell binding domain, complex, subtype, toxin
• Biological source: Clostridium botulinum str. Iwanei E
• Total number of polymer chains: 1
• Total formula weight: 52309.23

Authors

Gregory, K.S.,Acharya, K.R.,Liu, S.M.,Newell, A.R.,Mojanaga, O.O. (deposition date: 2022-07-20, release date: 2022-09-21, Last modification date: 2024-01-31)

• Primary citation: Gregory, K.S.,Newell, A.R.,Mojanaga, O.O.,Liu, S.M.,Acharya, K.R.; Crystal Structures of the Clostridium botulinum Neurotoxin A6 Cell Binding Domain Alone and in Complex with GD1a Reveal Significant Conformational Flexibility.; Int J Mol Sci, 23:-, 2022; PubMed: 36077016; DOI: 10.3390/ijms23179620

Experimental method

X-RAY DIFFRACTION (1.5 Å)