8AGJ

Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) variant K112A in complex with JMC31

8AGJ の概要

• エントリーDOI: 10.2210/pdb8agj/pdb
• 関連するPDBエントリー: 8AGI
• 分子名称: Heat shock protein HSP 90-alpha, 1-[2,4-bis(oxidanyl)-5-propan-2-yl-phenyl]-5-[4-[(cyclohexylmethylamino)methyl]phenyl]-~{N}-ethyl-1,2,3-triazole-4-carboxamide (3 entities in total)
• 機能のキーワード: hsp90, ntd, k112a, 1, 2, 3-triazole-based compound, complex, chaperone
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 58413.34

構造登録者

Tassone, G.,Pozzi, C.,Mazzorana, M.,Mangani, S.,Maramai, S. (登録日: 2022-07-20, 公開日: 2022-09-07, 最終更新日: 2024-01-31)

• 主引用文献: Tassone, G.,Mazzorana, M.,Mangani, S.,Petricci, E.,Cini, E.,Giannini, G.,Pozzi, C.,Maramai, S.; Structural Characterization of Human Heat Shock Protein 90 N-Terminal Domain and Its Variants K112R and K112A in Complex with a Potent 1,2,3-Triazole-Based Inhibitor.; Int J Mol Sci, 23:-, 2022; PubMed: 36012721; DOI: 10.3390/ijms23169458

実験手法

X-RAY DIFFRACTION (2.32 Å)