8AEC
Structure of Compound 17 bound to CK2alpha
Summary for 8AEC
| Entry DOI | 10.2210/pdb8aec/pdb |
| Descriptor | Casein kinase II subunit alpha, ADENOSINE-5'-TRIPHOSPHATE, ACETATE ION, ... (6 entities in total) |
| Functional Keywords | fragment based drug discovery, transferase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 40022.14 |
| Authors | Brear, P.,De Fusco, C.,Atkinson, E.,Iegre, I.,Francis, N.,Venkitaraman, A.,Spring, D.,Hyvonen, M. (deposition date: 2022-07-12, release date: 2022-10-12, Last modification date: 2024-02-07) |
| Primary citation | Brear, P.,De Fusco, C.,Atkinson, E.L.,Iegre, J.,Francis-Newton, N.J.,Venkitaraman, A.R.,Hyvonen, M.,Spring, D.R. A fragment-based approach leading to the discovery of inhibitors of CK2 alpha with a novel mechanism of action. Rsc Med Chem, 13:1420-1426, 2022 Cited by PubMed: 36426237DOI: 10.1039/d2md00161f PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.09 Å) |
Structure validation
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