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8AEC

Structure of Compound 17 bound to CK2alpha

Summary for 8AEC
Entry DOI10.2210/pdb8aec/pdb
DescriptorCasein kinase II subunit alpha, ADENOSINE-5'-TRIPHOSPHATE, ACETATE ION, ... (6 entities in total)
Functional Keywordsfragment based drug discovery, transferase
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight40022.14
Authors
Brear, P.,De Fusco, C.,Atkinson, E.,Iegre, I.,Francis, N.,Venkitaraman, A.,Spring, D.,Hyvonen, M. (deposition date: 2022-07-12, release date: 2022-10-12, Last modification date: 2024-02-07)
Primary citationBrear, P.,De Fusco, C.,Atkinson, E.L.,Iegre, J.,Francis-Newton, N.J.,Venkitaraman, A.R.,Hyvonen, M.,Spring, D.R.
A fragment-based approach leading to the discovery of inhibitors of CK2 alpha with a novel mechanism of action.
Rsc Med Chem, 13:1420-1426, 2022
Cited by
PubMed: 36426237
DOI: 10.1039/d2md00161f
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.09 Å)
Structure validation

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