8AE5

Crystal structure of human legumain in complex with macrocypin 1a

8AE5 の概要

• エントリーDOI: 10.2210/pdb8ae5/pdb
• 分子名称: Legumain, Macrocypin-1a, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: cysteine protease, ligase, asparaginyl endopeptidase, aep, inhibitor, exosite, active site, substrate, hydrolase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 102624.44

構造登録者

Elamin, T.,Brandstetter, H.,Dall, E. (登録日: 2022-07-12, 公開日: 2022-09-28, 最終更新日: 2024-01-31)

• 主引用文献: Elamin, T.,Santos, N.P.,Briza, P.,Brandstetter, H.,Dall, E.; Structural and functional studies of legumain-mycocypin complexes revealed a competitive, exosite-regulated mode of interaction.; J.Biol.Chem., 298:102502-102502, 2022; PubMed: 36116553; DOI: 10.1016/j.jbc.2022.102502

実験手法

X-RAY DIFFRACTION (2.29 Å)