8ACI

Structure of ARG-117 Fab in complex with a fragment of complement C2, neutral pH

Summary for 8ACI

• Entry DOI: 10.2210/pdb8aci/pdb
• Descriptor: Complement C2b fragment, ARGX-117 Fab heavy chain, nanobody specific for kappa light chain of Fab, ... (9 entities in total)
• Functional Keywords: innate immune system, antibody, complement, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 83164.69

Authors

Olesen, H.G.,Andersen, G.R. (deposition date: 2022-07-05, release date: 2024-01-17, Last modification date: 2024-10-23)

• Primary citation: Olesen, H.G.,Andersen, G.R.; Structure-function analysis of ARGX-117, a calcium- and pH-dependent clinical phase complement C2 blocking antibody; To be published,

Experimental method

X-RAY DIFFRACTION (1.85 Å)