8AAU

LIM Domain Kinase 1 (LIMK1) bound to LIMKi3

Summary for 8AAU

Entry DOI	10.2210/pdb8aau/pdb
Descriptor	LIM domain kinase 1, 1,2-ETHANEDIOL, ~{N}-[5-[2-[2,6-bis(chloranyl)phenyl]-5-[bis(fluoranyl)methyl]pyrazol-3-yl]-1,3-thiazol-2-yl]-2-methyl-propanamide, ... (6 entities in total)
Functional Keywords	kinase small-molecule inhibitor cfl-1 actin cytoskeleton dynamics, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	36800.62
Authors	Mathea, S.,Salah, E.,Hanke, T.,Knapp, S. (deposition date: 2022-07-03, release date: 2022-08-10, Last modification date: 2024-02-07)
Primary citation	Hanke, T.,Mathea, S.,Woortman, J.,Salah, E.,Berger, B.T.,Tumber, A.,Kashima, R.,Hata, A.,Kuster, B.,Muller, S.,Knapp, S. Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes. J.Med.Chem., 65:13264-13287, 2022 Cited by PubMed: 36136092 DOI: 10.1021/acs.jmedchem.2c01106 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.74 Å)

Structure validation