8A8Z

Crystal structure of Danio rerio HDAC6 CD2 in complex with in situ enzymatically hydrolyzed DFMO-based ITF5924

8A8Z の概要

• エントリーDOI: 10.2210/pdb8a8z/pdb
• 分子名称: Histone deacetylase 6, 4-[[4-[4-(imidazolidin-2-ylideneamino)phenyl]-1,2,3-triazol-1-yl]methyl]benzohydrazide, ZINC ION, ... (5 entities in total)
• 機能のキーワード: histone deacetylase, complex with hydrazide, hydrolase, non-hydroxamate zinc binding group, mechanism-based inhibitor
• 由来する生物種: Danio rerio (zebrafish)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 81725.11

構造登録者

Zrubek, K.,Sandrone, G.,Cukier, C.D.,Stevenazzi, A. (登録日: 2022-06-27, 公開日: 2023-01-25, 最終更新日: 2024-02-07)

• 主引用文献: Cellupica, E.,Caprini, G.,Cordella, P.,Cukier, C.,Fossati, G.,Marchini, M.,Rocchio, I.,Sandrone, G.,Vanoni, M.A.,Vergani, B.,Zrubek, K.,Stevenazzi, A.,Steinkuhler, C.; Difluoromethyl-1,3,4-oxadiazoles are slow-binding substrate analog inhibitors of histone deacetylase 6 with unprecedented isotype selectivity.; J.Biol.Chem., 299:102800-102800, 2022; PubMed: 36528061; DOI: 10.1016/j.jbc.2022.102800

実験手法

X-RAY DIFFRACTION (1.6 Å)