8A7N

Crystal Structure of human Brachyury G177D variant in complex with (S)-N-(3-aminopropyl)-3-((1-(2-fluorophenyl)-2-oxopyrrolidin-3-yl)amino)-N-methylbenzamide (CF-2-125)

Summary for 8A7N

• Entry DOI: 10.2210/pdb8a7n/pdb
• Descriptor: T-box transcription factor T, PHOSPHATE ION, N-(3-azanylpropyl)-3-[[(3S)-1-(2-fluorophenyl)-2-oxidanylidene-pyrrolidin-3-yl]amino]-N-methyl-benzamide, ... (4 entities in total)
• Functional Keywords: brachyury, chordoma, tbxt, transcription
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 20135.04

Authors

Newman, J.A.,Gavard, A.,Aitkenhead, H.,Imprachim, N.,Sherestha, L.,Burgess-Brown, N.A.,von Delft, F.,Bountra, C.,Gileadi, O. (deposition date: 2022-06-21, release date: 2022-10-05, Last modification date: 2024-01-31)

• Primary citation: Newman, J.A.,Gavard, A.,Aitkenhead, H.,Imprachim, N.,Sherestha, L.,Burgess-Brown, N.A.,von Delft, F.,Bountra, C.,Gileadi, O.; Crystal Structure of human Brachyury G177D variant in complex with (S)-N-(3-aminopropyl)-3-((1-(2-fluorophenyl)-2-oxopyrrolidin-3-yl)amino)-N-methylbenzamide (CF-2-125); To Be Published,

Experimental method

X-RAY DIFFRACTION (1.9 Å)