8A7N

Crystal Structure of human Brachyury G177D variant in complex with (S)-N-(3-aminopropyl)-3-((1-(2-fluorophenyl)-2-oxopyrrolidin-3-yl)amino)-N-methylbenzamide (CF-2-125)

8A7N の概要

• エントリーDOI: 10.2210/pdb8a7n/pdb
• 分子名称: T-box transcription factor T, PHOSPHATE ION, N-(3-azanylpropyl)-3-[[(3S)-1-(2-fluorophenyl)-2-oxidanylidene-pyrrolidin-3-yl]amino]-N-methyl-benzamide, ... (4 entities in total)
• 機能のキーワード: brachyury, chordoma, tbxt, transcription
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20135.04

構造登録者

Newman, J.A.,Gavard, A.,Aitkenhead, H.,Imprachim, N.,Sherestha, L.,Burgess-Brown, N.A.,von Delft, F.,Bountra, C.,Gileadi, O. (登録日: 2022-06-21, 公開日: 2022-10-05, 最終更新日: 2024-01-31)

• 主引用文献: Newman, J.A.,Gavard, A.,Aitkenhead, H.,Imprachim, N.,Sherestha, L.,Burgess-Brown, N.A.,von Delft, F.,Bountra, C.,Gileadi, O.; Crystal Structure of human Brachyury G177D variant in complex with (S)-N-(3-aminopropyl)-3-((1-(2-fluorophenyl)-2-oxopyrrolidin-3-yl)amino)-N-methylbenzamide (CF-2-125); To Be Published,

実験手法

X-RAY DIFFRACTION (1.9 Å)