8A7E
PAPP-A dimer in complex with its inhibitor STC2
Summary for 8A7E
Entry DOI | 10.2210/pdb8a7e/pdb |
Related | 8A7D |
EMDB information | 15217 15219 15220 15221 |
Descriptor | Stanniocalcin-2, Pappalysin-1, ZINC ION, ... (4 entities in total) |
Functional Keywords | metzincin metalloprotease inhibitor complex, hydrolase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 380904.07 |
Authors | Kobbero, S.D.,Gajhede, M.,Mirza, O.A.,Boesen, T.,Oxvig, C. (deposition date: 2022-06-20, release date: 2022-11-02) |
Primary citation | Kobbero, S.D.,Gajhede, M.,Mirza, O.A.,Kloverpris, S.,Kjaer, T.R.,Mikkelsen, J.H.,Boesen, T.,Oxvig, C. Structure of the proteolytic enzyme PAPP-A with the endogenous inhibitor stanniocalcin-2 reveals its inhibitory mechanism. Nat Commun, 13:6084-6084, 2022 Cited by PubMed: 36257932DOI: 10.1038/s41467-022-33698-8 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (5.02 Å) |
Structure validation
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