8A4V

Crystal structure of human cathepsin L with covalently bound E-64

Summary for 8A4V

Entry DOI	10.2210/pdb8a4v/pdb
Related	7ZS7 7ZVF 7ZXA 8A4U
Descriptor	Cathepsin L, N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE, DI(HYDROXYETHYL)ETHER, ... (6 entities in total)
Functional Keywords	cystein protease, drug target, lysosome, virus cell entry, hydrolase, proteinase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	99003.59
Authors	Falke, S.,Lieske, J.,Guenther, S.,Reinke, P.Y.A.,Ewert, W.,Loboda, J.,Karnicar, K.,Usenik, A.,Lindic, N.,Sekirnik, A.,Chapman, H.N.,Hinrichs, W.,Turk, D.,Meents, A. (deposition date: 2022-06-13, release date: 2023-07-05, Last modification date: 2024-05-22)
Primary citation	Falke, S.,Lieske, J.,Herrmann, A.,Loboda, J.,Karnicar, K.,Gunther, S.,Reinke, P.Y.A.,Ewert, W.,Usenik, A.,Lindic, N.,Sekirnik, A.,Dretnik, K.,Tsuge, H.,Turk, V.,Chapman, H.N.,Hinrichs, W.,Ebert, G.,Turk, D.,Meents, A. Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors. J.Med.Chem., 67:7048-7067, 2024 Cited by PubMed: 38630165 DOI: 10.1021/acs.jmedchem.3c02351 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation