8A4V
Crystal structure of human cathepsin L with covalently bound E-64
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Cathepsin L | polymer | 220 | 24161.7 | 4 | UniProt (P07711) Pfam (PF00112) In PDB | Homo sapiens (human) | |
2 | A, B, C, D | N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE | non-polymer | 360.4 | 4 | Chemie (E64) | |||
3 | A, B, C, D | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 5 | Chemie (PEG) | |||
4 | B, D | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 3 | Chemie (DMS) | |||
5 | C | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
6 | water | water | 18.0 | 798 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 220 (UniProt: P07711)
PDB | External Database | Details |
---|---|---|
Ala 110 | Thr 223 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 96646.7 | |
Non-Polymers* | Number of molecules | 13 |
Total formula weight | 2356.9 | |
All* | Total formula weight | 99003.6 |