8A2Q

Structure of the DNA-bound FANCD2-FANCI complex containing phosphomimetic FANCI

Summary for 8A2Q

Entry DOI	10.2210/pdb8a2q/pdb
EMDB information	15101 15102 15103
Descriptor	FANCD2, Fanconi anemia complementation group I, DNA (29-MER), ... (4 entities in total)
Functional Keywords	nucleic acid protein complex, dna clamp, solenoid domains, fanconi anemia, dna repair, dna damage, dna inter strand crosslink, dna binding protein, ubiquitination, atr, pathway activation
Biological source	Gallus gallus (chicken) More
Total number of polymer chains	4
Total formula weight	342184.91
Authors	Passmore, L.A.,Sijacki, T.,Alcon, P. (deposition date: 2022-06-06, release date: 2022-09-07, Last modification date: 2022-10-05)
Primary citation	Sijacki, T.,Alcon, P.,Chen, Z.A.,McLaughlin, S.H.,Shakeel, S.,Rappsilber, J.,Passmore, L.A. The DNA-damage kinase ATR activates the FANCD2-FANCI clamp by priming it for ubiquitination. Nat.Struct.Mol.Biol., 29:881-890, 2022 Cited by PubMed: 36050501 DOI: 10.1038/s41594-022-00820-9 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.53 Å)

Structure validation