8A2D

EGFR kinase domain (L858R/V948R) in complex with 2-[4-(difluoromethyl)-6-[2-[4-[[4-(hydroxymethyl)-1-piperidyl]methyl]phenyl]ethynyl]-7-methyl-indazol-2-yl]-2-spiro[6,7-dihydropyrrolo[1,2-c]imidazole-5,1'-cyclopropane]-1-yl-N-thiazol-2-yl-acetamide

Summary for 8A2D

• Entry DOI: 10.2210/pdb8a2d/pdb
• Related: 8A27 8A2A 8A2B
• Descriptor: Epidermal growth factor receptor, 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (5 entities in total)
• Functional Keywords: kinase inhibitor, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 38266.30

Authors

Kuglstatter, A.,Ehler, A. (deposition date: 2022-06-03, release date: 2022-10-19, Last modification date: 2024-01-31)

• Primary citation: Obst-Sander, U.,Ricci, A.,Kuhn, B.,Friess, T.,Koldewey, P.,Kuglstatter, A.,Hewings, D.,Goergler, A.,Steiner, S.,Rueher, D.,Imhoff, M.P.,Raschetti, N.,Marty, H.P.,Dietzig, A.,Rynn, C.,Ehler, A.,Burger, D.,Kornacker, M.,Schaffland, J.P.,Herting, F.,Pao, W.,Bischoff, J.R.,Martoglio, B.,Alice Nagel, Y.,Jaeschke, G.; Discovery of Novel Allosteric EGFR L858R Inhibitors for the Treatment of Non-Small-Cell Lung Cancer as a Single Agent or in Combination with Osimertinib.; J.Med.Chem., 65:13052-13073, 2022; PubMed: 36178776; DOI: 10.1021/acs.jmedchem.2c00893

Experimental method

X-RAY DIFFRACTION (1.11 Å)