8A1K
Crystal structure of the transpeptidase LdtMt2 from Mycobacterium tuberculosis in complex with ebsulfur analogue 15
Summary for 8A1K
Entry DOI | 10.2210/pdb8a1k/pdb |
Descriptor | L,D-transpeptidase 2, 4,5-bis(chloranyl)-N-(2-hydroxyethyl)-2-sulfanyl-benzamide, 1,2-ETHANEDIOL, ... (6 entities in total) |
Functional Keywords | l, d-transpeptidase, ldtmt2, inhibitor, covalent, antimicrobial protein |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 2 |
Total formula weight | 76775.84 |
Authors | de Munnik, M.,Lang, P.A.,Brem, J.,Schofield, C.J. (deposition date: 2022-06-01, release date: 2023-06-14, Last modification date: 2024-02-07) |
Primary citation | de Munnik, M.,Lang, P.A.,De Dios Anton, F.,Cacho, M.,Bates, R.H.,Brem, J.,Rodriguez Miquel, B.,Schofield, C.J. High-throughput screen with the l,d-transpeptidase Ldt Mt2 of Mycobacterium tuberculosis reveals novel classes of covalently reacting inhibitors. Chem Sci, 14:7262-7278, 2023 Cited by PubMed: 37416715DOI: 10.1039/d2sc06858c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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