8A12

Plasmodium falciparum Myosin A full-length, post-rigor state complexed to Mg.ATP-gamma-S

8A12 の概要

• エントリーDOI: 10.2210/pdb8a12/pdb
• 分子名称: Myosin-A, Myosin A tail domain interacting protein, Myosin essential light chain ELC, ... (8 entities in total)
• 機能のキーワード: malaria, plasmodium falciparum, myosin a, knx002, antimalarial treatment, molecular motors, motor protein
• 由来する生物種: Plasmodium falciparum (malaria parasite P. falciparum); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 132445.61

構造登録者

Moussaoui, D.,Robblee, J.P.,Auguin, D.,Fisher, F.,Fagnant, P.M.,MacFarlane, J.E.,Mueller-Dieckmann, C.,Baum, J.,Robert-Paganin, J.,Trybus, K.M.,Houdusse, A. (登録日: 2022-05-31, 公開日: 2023-06-21, 最終更新日: 2024-02-07)

• 主引用文献: Moussaoui, D.,Robblee, J.P.,Robert-Paganin, J.,Auguin, D.,Fisher, F.,Fagnant, P.M.,Macfarlane, J.E.,Schaletzky, J.,Wehri, E.,Mueller-Dieckmann, C.,Baum, J.,Trybus, K.M.,Houdusse, A.; Mechanism of small molecule inhibition of Plasmodium falciparum myosin A informs antimalarial drug design.; Nat Commun, 14:3463-3463, 2023; PubMed: 37308472; DOI: 10.1038/s41467-023-38976-7

実験手法

X-RAY DIFFRACTION (2.03 Å)