8A0U

Crystal structure of TEAD3 in complex with CPD4

Summary for 8A0U

• Entry DOI: 10.2210/pdb8a0u/pdb
• Descriptor: Transcriptional enhancer factor TEF-5, MYRISTIC ACID, 2-[(2~{S})-2-(aminomethyl)-5-chloranyl-2-phenyl-3~{H}-1-benzofuran-4-yl]benzamide, ... (5 entities in total)
• Functional Keywords: inhibitor, complex, transcription
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 104524.02

Authors

Scheufler, C.,Kallen, J. (deposition date: 2022-05-30, release date: 2022-08-17, Last modification date: 2022-10-19)

• Primary citation: Furet, P.,Bordas, V.,Le Douget, M.,Salem, B.,Mesrouze, Y.,Imbach-Weese, P.,Sellner, H.,Voegtle, M.,Soldermann, N.,Chapeau, E.,Wartmann, M.,Scheufler, C.,Fernandez, C.,Kallen, J.,Guagnano, V.,Chene, P.,Schmelzle, T.; The First Class of Small Molecules Potently Disrupting the YAP-TEAD Interaction by Direct Competition.; Chemmedchem, 17:e202200303-e202200303, 2022; PubMed: 35950546; DOI: 10.1002/cmdc.202200303

Experimental method

X-RAY DIFFRACTION (2.895 Å)