8ZH4

HIV-1 integrase core domain in complex with compound 5

This is a non-PDB format compatible entry.

Summary for 8ZH4

• Entry DOI: 10.2210/pdb8zh4/pdb
• Descriptor: Integrase, TETRAETHYLENE GLYCOL, (2~{S})-2-(4',5-dimethylspiro[1,2-dihydroindene-3,1'-cyclohexane]-4-yl)-2-[(2-methylpropan-2-yl)oxy]ethanoic acid, ... (5 entities in total)
• Functional Keywords: hiv, integrase, inhibitor, viral protein
• Biological source: Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE)
• Total number of polymer chains: 1
• Total formula weight: 19174.53

Authors

Furuzono, T.,Orita, T.,Nomura, A.,Adachi, T. (deposition date: 2024-05-10, release date: 2024-07-10, Last modification date: 2024-07-24)

• Primary citation: Adachi, K.,Manabe, T.,Yamasaki, T.,Suma, A.,Orita, T.,Furuzono, T.,Adachi, T.,Ohata, Y.,Akiyama, Y.,Miyazaki, S.; Design and synthesis of novel and potent allosteric HIV-1 integrase inhibitors with a spirocyclic moiety.; Bioorg.Med.Chem.Lett., 110:129864-129864, 2024; PubMed: 38942126; DOI: 10.1016/j.bmcl.2024.129864

Experimental method

X-RAY DIFFRACTION (1.82 Å)