8XAM
Co-crystal structure of compound 7 in complex with MAT2A
Summary for 8XAM
Entry DOI | 10.2210/pdb8xam/pdb |
Descriptor | S-adenosylmethionine synthase isoform type-2, S-ADENOSYLMETHIONINE, 2-[3-[7-chloranyl-4-(dimethylamino)-2-oxidanylidene-quinazolin-1-yl]phenoxy]-~{N}-[3-[7-chloranyl-4-(dimethylamino)-2-oxidanylidene-quinazolin-1-yl]phenyl]ethanamide, ... (4 entities in total) |
Functional Keywords | mat2a inhibitor, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 85470.96 |
Authors | |
Primary citation | Gao, F.,Ding, X.,Cao, Z.,Zhu, W.,Fan, Y.,Steurer, B.,Wang, H.,Cai, X.,Zhang, M.,Aliper, A.,Ren, F.,Ding, X.,Zhavoronkov, A. Discovery of novel MAT2A inhibitors by an allosteric site-compatible fragment growing approach. Bioorg.Med.Chem., 100:117633-117633, 2024 Cited by PubMed: 38342078DOI: 10.1016/j.bmc.2024.117633 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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