8VXE
Structure of p38 alpha (Mitogen-activated protein kinase 14) complexed with inhibitor 6
This is a non-PDB format compatible entry.
Summary for 8VXE
Entry DOI | 10.2210/pdb8vxe/pdb |
Descriptor | Mitogen-activated protein kinase 14, (4M)-4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridine (3 entities in total) |
Functional Keywords | kinase, transferase, p38 alpha, mapk14, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 45242.30 |
Authors | Blaesse, M.,Steinbacher, S.,Shaffer, P.L.,Sharma, S.,Thompson, A.A. (deposition date: 2024-02-04, release date: 2024-05-08) |
Primary citation | McCarver, S.,Hanna, L.,Samant, A.,Thompson, A.A.,Seierstad, M.,Saha, A.,Wu, D.,Lord, B.,Sutton, S.W.,Shah, V.,Milligan, C.M.,Wennerholm, M.,Shelton, J.,Lebold, T.P.,Shireman, B.T. Structure-Based Optimization of Selective and Brain Penetrant CK1 delta Inhibitors for the Treatment of Circadian Disruptions. Acs Med.Chem.Lett., 15:486-492, 2024 Cited by PubMed: 38628796DOI: 10.1021/acsmedchemlett.3c00523 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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