8VJP
Histidine-covalent stapled alpha-helical peptide (155H1) targeting hMcl-1
This is a non-PDB format compatible entry.
Summary for 8VJP
Entry DOI | 10.2210/pdb8vjp/pdb |
Descriptor | Induced myeloid leukemia cell differentiation protein Mcl-1, Histidine-covalent stapled alpha-helical peptide, (S~1~R)-3-carbamoyl-4-methoxybenzene-1-sulfinic acid, ... (5 entities in total) |
Functional Keywords | histidine-covalent stapled alpha-helical peptides, apoptosis |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 19609.36 |
Authors | Muzzarelli, K.M.,Assar, Z.,Alboreggia, G.,Pellecchia, M. (deposition date: 2024-01-07, release date: 2024-05-15, Last modification date: 2024-06-05) |
Primary citation | Alboreggia, G.,Udompholkul, P.,Baggio, C.,Muzzarelli, K.,Assar, Z.,Pellecchia, M. Histidine-Covalent Stapled Alpha-Helical Peptides Targeting hMcl-1. J.Med.Chem., 67:8172-8185, 2024 Cited by PubMed: 38695666DOI: 10.1021/acs.jmedchem.4c00277 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.13 Å) |
Structure validation
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