8VJP
Histidine-covalent stapled alpha-helical peptide (155H1) targeting hMcl-1
This is a non-PDB format compatible entry.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Induced myeloid leukemia cell differentiation protein Mcl-1 | polymer | 156 | 17850.3 | 1 | UniProt (Q07820) Pfam (PF00452) In PDB | Homo sapiens (human) | Bcl-2-like protein 3,Bcl2-L-3,Bcl-2-related protein EAT/mcl1,mcl1/EAT |
2 | B | Histidine-covalent stapled alpha-helical peptide | polymer | 15 | 1415.6 | 1 | synthetic construct | ||
3 | A | (S~1~R)-3-carbamoyl-4-methoxybenzene-1-sulfinic acid | non-polymer | 215.2 | 1 | Chemie (A1AJE) | |||
4 | B | (4Z)-oct-4-en-1-ol | non-polymer | 128.2 | 1 | Chemie (A1AJD) | |||
5 | water | water | 18.0 | 225 | Chemie (HOH) |
Sequence modifications
A: 172 - 323 (UniProt: Q07820)
PDB | External Database | Details |
---|---|---|
Gly 168 | - | expression tag |
Ser 169 | - | expression tag |
His 170 | - | expression tag |
Met 171 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 19265.9 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 343.4 | |
All* | Total formula weight | 19609.4 |