8VEX
Crystal structure of PRMT5:MEP50 in complex with MTA and oxamide compound 28
This is a non-PDB format compatible entry.
Summary for 8VEX
Entry DOI | 10.2210/pdb8vex/pdb |
Descriptor | Protein arginine N-methyltransferase 5, Methylosome protein 50, 5'-DEOXY-5'-METHYLTHIOADENOSINE, ... (7 entities in total) |
Functional Keywords | mtap-null, sam, mta, inhibitor, mta-cooperative, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 112454.79 |
Authors | Whittington, D.A. (deposition date: 2023-12-20, release date: 2024-04-24, Last modification date: 2024-05-08) |
Primary citation | Cottrell, K.M.,Briggs, K.J.,Whittington, D.A.,Jahic, H.,Ali, J.A.,Davis, C.B.,Gong, S.,Gotur, D.,Gu, L.,McCarren, P.,Tonini, M.R.,Tsai, A.,Wilker, E.W.,Yuan, H.,Zhang, M.,Zhang, W.,Huang, A.,Maxwell, J.P. Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP -Deleted Cancers. J.Med.Chem., 67:6064-6080, 2024 Cited by PubMed: 38595098DOI: 10.1021/acs.jmedchem.4c00133 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.79 Å) |
Structure validation
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