8V8A
Alpha7-nicotinic acetylcholine receptor time resolved bound to epibatidine and PNU-120596 desensitized intermediate state
Summary for 8V8A
Entry DOI | 10.2210/pdb8v8a/pdb |
Related | 8UT1 8UTB 8UZJ 8V80 8V82 8V86 8V88 8V89 8V8C 8V8D |
EMDB information | 43032 |
Descriptor | Neuronal acetylcholine receptor subunit alpha-7,Soluble cytochrome b562, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total) |
Functional Keywords | ion channel, membrane protein, nicotinic receptor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 5 |
Total formula weight | 359192.34 |
Authors | Burke, S.M.,Noviello, C.M.,Hibbs, R.E. (deposition date: 2023-12-05, release date: 2024-02-21, Last modification date: 2024-03-13) |
Primary citation | Burke, S.M.,Avstrikova, M.,Noviello, C.M.,Mukhtasimova, N.,Changeux, J.P.,Thakur, G.A.,Sine, S.M.,Cecchini, M.,Hibbs, R.E. Structural mechanisms of alpha 7 nicotinic receptor allosteric modulation and activation. Cell, 187:1160-1176.e21, 2024 Cited by PubMed: 38382524DOI: 10.1016/j.cell.2024.01.032 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.19 Å) |
Structure validation
Download full validation report