8V52

Crystal structure of 2A10 Fab bound to Human TGF-beta3

Summary for 8V52

• Entry DOI: 10.2210/pdb8v52/pdb
• Descriptor: Transforming growth factor beta-3, 2A10 Fab Light chain, 2A10 Fab Heavy Chain, ... (4 entities in total)
• Functional Keywords: tgf beta, 2a10, complex, fab, cytokine, cytokine-immune system complex, cytokine/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 121433.79

Authors

Yin, J.,Lupardus, P.J. (deposition date: 2023-11-30, release date: 2024-04-10)

• Primary citation: Sun, T.,Vander Heiden, J.A.,Gao, X.,Yin, J.,Uttarwar, S.,Liang, W.C.,Jia, G.,Yadav, R.,Huang, Z.,Mitra, M.,Halpern, W.,Bender, H.S.,Brightbill, H.D.,Wu, Y.,Lupardus, P.,Ramalingam, T.,Arron, J.R.; Isoform-selective TGF-beta 3 inhibition for systemic sclerosis.; Med, 5:132-147.e7, 2024; PubMed: 38272035; DOI: 10.1016/j.medj.2023.12.011

Experimental method

X-RAY DIFFRACTION (2.5 Å)