8V2F
Crystal structure of IRAK4 kinase domain with compound 9
Summary for 8V2F
Entry DOI | 10.2210/pdb8v2f/pdb |
Related | 8V1O |
Descriptor | Interleukin-1 receptor-associated kinase 4, N-{2-[(1r,4r)-4-(hydroxymethyl)cyclohexyl]-6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl}-6-(trifluoromethyl)pyridine-2-carboxamide, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | kinase important for immune response. protac design, immune system |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 151371.61 |
Authors | Weiss, M.M.,Zheng, X.,Browne, C.M.,Campbell, V.,Chen, D.,Enerson, B.,Fei, X.,Huang, X.,Klaus, C.R.,Li, H.,Mayo, M.,McDonald, A.A.,Paul, A.,Sharma, K.,Shi, Y.,Slavin, A.,Walter, D.M.,Yuan, K.,Zhang, Y.,Zhu, X.,Kelleher, J.,Ji, N.,Walker, D.,Mainolfi, N. (deposition date: 2023-11-22, release date: 2024-07-03, Last modification date: 2024-07-24) |
Primary citation | Weiss, M.M.,Zheng, X.,Ji, N.,Browne, C.M.,Campbell, V.,Chen, D.,Enerson, B.,Fei, X.,Huang, X.,Klaus, C.R.,Li, H.,Mayo, M.,McDonald, A.A.,Paul, A.,Rong, H.,Sharma, K.,Shi, Y.,Slavin, A.,Walther, D.M.,Yuan, K.,Zhang, Y.,Zhu, X.,Kelleher, J.,Walker, D.,Mainolfi, N. Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B-Cell Lymphoma. J.Med.Chem., 67:10548-10566, 2024 Cited by PubMed: 38920289DOI: 10.1021/acs.jmedchem.3c01823 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.09 Å) |
Structure validation
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